Action-at-a-distance interactions enhance protein binding affinity
نویسندگان
چکیده
منابع مشابه
Action-at-a-Distance Interactions that Enhance Molecular Binding Affinity
The Problem: Current design and optimization methods for improving protein–protein interactions are intimately dependent on the atomic-level details of molecular structure. Dead-end elimination [2, 9, 10], self-consistent meanfield [6, 7, 8], simulated annealing [3, 11], and genetic algorithms [1, 4] all attempt to repack a binding interface with improved interactions to enhance binding affinit...
متن کاملRecognizing Action at a Distance
Our goal is to recognize human actions at a distance, at resolutions where a whole person may be, say, 30 pixels tall. We introduce a novel motion descriptor based on optical flow measurements in a spatio-temporal volume for each stabilized human figure, and an associated similarity measure to be used in a nearest-neighbor framework. Making use of noisy optical flow measurements is the key chal...
متن کاملAtomic Interactions at a Distance
Van der Waals (vdW) forces are the dominant interactions between neutral particles on nanometer-tomicrometer length scales. This makes their effects ubiquitous in physics, chemistry, and biology: they are, for instance, responsible for the action of detergents, the selfassembly of viruses, and even the ability of geckos to climb flat surfaces. Their existence was first proposed by Johannes Dide...
متن کاملAction at a Distance in Quantum Theory
The purpose of this paper is to present a consistent mathematical framework that shows how the EPR (Einstein. Podolsky, Rosen) phenomenon fits into our view of space time. To resolve the differences between the Hilbert space structure of quantum theory and the manifold structure of classical physics, the manifold is taken as a partial representation of the Hilbert space. It is the partial natur...
متن کاملSpooky Action at a Temporal Distance
Since the discovery of Bell’s theorem, the physics community has come to take seriously the possibility that the universe might contain physical processes which are spatially nonlocal, but there has been no such revolution with regard to the possibility of temporally nonlocal processes. In this article, we argue that the assumption of temporal locality is actively limiting progress in the field...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 2005
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.041283105